Clinical Trial Finder

Inclusion Criteria:

1. Age greater than or equal to 18 years old ,male or female; 2. Patients diagnosed with Primary Myelofibrosis according to WHO standard (2016 version), or patients diagnosed with Post-Polycythemia Vera Myelofibrosis or Post-Essential Thrombocythemia Myelofibrosis according to International Working Group Myeloproliferative Neoplasms Research and Treatment(IWG-MRT) standard. Both Janus Kinase 2(JAK2)mutation and JAK2 wild can be enrolled； 3. According to Dynamic International Prognostic Scoring System plus(DIPSS-plus) risk grouping criteria, patients with medium-risk-2 or high-risk myelofibrosis were assessed,Patients with grade 1 medium-risk myelofibrosis with hepatosplenomegaly and no response to existing treatment and requiring treatment can also be enrolled; 4. Patients who have received or are receiving Ruxolitinib,and：Ruxolitinib treatment time is not less than 28 days;Red blood cell transfusion is still needed during treatment with Ruxolitinib；or Ruxolitinib dose (including starting dose and adjusted dose)<20mg bid，And must meet at least one of the following：Level 3 or higher platelet count reduction or Level 3 or higher anemia or Level 3 or higher hematoma/bleeding； 5. a life expectancy > 24 weeks; 6. Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 2； 7. Splenomegaly: palpation of the splenic margin to or above the subcostal at least 5cm； 8. Within 14 days before enrollment，The Laboratory indicators meet the following criteria：

• - Absolute neutrophil count（ANC） > 0.75 x 10^9/L，blood platelet count> 30 x 10^9/L,And no colony stimulating factor was used within 7 days before screening; - Peripheral blood blast < 10%; - AST和ALT≤3xULN，Patients with severe extramedullary hematopoiesis or who have received iron therapy within 60 days prior to screening and thus have liver function damage,AST和ALT≤5xULN ； - Direct bilirubin≤2.0*ULN.

• - Creatinine clearance≥45mL/min； 9.

Meet the requirements of the Ethics Committee, voluntarily sign an informed consent form； 10. Ability to follow research and follow-up procedures；

Exclusion Criteria:

1. Any significant clinical or laboratory abnormalities that the investigator considers to affect safety assessment, such as: a. uncontrolled diabetes (> 250 mg/dL, or 13.9>mmol/L), b. had high blood pressure and antihypertensive drug treatment under two or unable to descend to the ranges (systolic blood pressure < 160 mmHg, diastolic pressure < 100 mmHg), c. peripheral neuropathy (NCI

• - CTC AE v5.0 standard grade 2 or above), etc; 2.

The patients who had a history of congestive heart failure(NCI

• - CTC AE v5.0 standard grade 3or above), uncontrollable or unstable angina or myocardial infarction, cerebrovascular accident or pulmonary embolism in the first 6 months; 3.

Screening of patients who have surgery within the first 4 weeks; 4. Screening for patients with arrhythmia requiring treatment or QTc interval (QTcB) >480ms; 5. Screening for bacterial, viral, parasitic or fungal infections that require treatment; 6. Patients which have with a history of congenital or acquired hemorrhagic diseases;(Note:With the exception of hematoma which caused by Ruxolitinib) 7. Splenectomy patients or in the group carried out within three months before the spleen radiation treatment (including internal radiation and external radiation) 8. Screening HIV, HBV DNA positive or higher than the normal reference range, or HCV RNA positive for HCV antibody; 9. Women who are planning to become pregnant or who are pregnant or breast- feeding, as well as those who were unable to use effective contraceptives throughout the trial;Male patients who do not use condoms during the administration and within 2 days (approximately 5 half-lives) after the last administration; 10. Patients who have suffered from malignant tumors (except cured basal cell carcinoma of the skin and carcinoma in situ of the cervix) in the past 5 years; Combined with other serious diseases, the researchers believe that patients' safety or compliance may be affected; 11. With other serious diseases, the researchers think that may affect patient safety or compliance; 12. The patients who had used the Jakatinib hydrochloride; 13. Patients who have participated in the clinical trials of other new drugs or medical devices within the first 1 months; 14. The patients who used the Hematopoietic growth factors within 14 days before Into the group (granulocyte growth factors, or platelet hormone) ； 15. Patients who cannot cooperate with or cannot perform MRI or CT scans； 16. Patients with refractory or recurrent myelofibrosis: refractory of myelofibrosis:After at least 28 days of adequate administration of JAK inhibitors, the spleen palpation was less than 15% smaller than before administration.Or at least 3 months later, the spleen volume on MRI/CT decreased by <10% compared with that before the administration. Recurrence of myelofibrosis: after at least 3 months of taking adequate amount of JAK inhibitor, the spleen was enlarged again after shrinking compared with that before taking the drug, and compared with the minimum value during taking the drug, the spleen volume increased ≥10% on MRI/CT examination or ≥30% on spleen palpation. 17. Any treatment MF medication (eg hydroxyurea,except ruxolitinib ), any immunomodulation used within 2 weeks prior to enrollment Agent (such as thalidomide), any immunosuppressant, glucocorticoids ≥ 10 mg/day of prednisone or equivalent biological strength, or patients within 6 half-life of the drug, over time Prevail;Patients who had received rucotinib within 1 week prior to enrolling

dose exploration: It is planned to enroll about 6 subjects. According to the baseline value of platelet count at the time of enrollment, different doses (100mg Qd or 150mg Qd or 200mg Qd or 100mg Bid) of Jaktinib Hydrochloride Tablets will be Treated. The trial is in progress Adjust the dose according to relevant laboratory indicators. When at least one subject has a spleen volume reduction of ≥35% from the baseline, the sponsor and the investigator will jointly decide whether to enter the extended study part. Extended research: It is planned to enroll about 43 subjects, and the initial dosage of Jaktinib Hydrochloride Tablets is planned to be 100mg Bid.

Arms

Experimental: Jaktinib Hydrochloride Tablets 100mg twice a day.

This is the dose group was given Jaktinib Hydrochloride Tablets 100mg （2 tablets）dose group for twice a day.

Experimental: Jaktinib Hydrochloride Tablets 150mg once a day

This is the dose group was given Jaktinib Hydrochloride Tablets 150mg （3 tablets）dose group for once a day.

Experimental: Jaktinib Hydrochloride Tablets 100mg once a day

This is the dose group was given Jaktinib Hydrochloride Tablets 100mg （2 tablets） dose group for once a day

Experimental: Jaktinib Hydrochloride Tablets 200mg once a day

This is the dose group was given Jaktinib Hydrochloride Tablets 200mg （4 tablets）dose group for once a day.

Interventions

Drug: - Jaktinib hydrochloride tablets

Jaktinib hydrochloride tablets 100mg twice dose group，Jaktinib hydrochloride tablets 150mg qd dose group, Jaktinib hydrochloride tablets 200mg qd dose group and Jaktinib hydrochloride tablets 100mg qd dose group