Study of Oral Navitoclax Tablet in Combination With Oral Ruxolitinib Tablet to Assess Change in Spleen Volume in Adult Participants With Relapsed/Refractory Myelofibrosis
Study Purpose
Myelofibrosis (MF) is a rare blood cancer, notable for scarring of the bone marrow (the spongy tissue inside bones) and the spleen becoming larger. The purpose of this study is to assess safety and change in spleen volume when navitoclax is given in combination with ruxolitinib, compared to best available therapy, for adult participants with MF. Navitoclax is an investigational drug (not yet approved) being developed for the treatment of MF. Participants in this study will be randomly selected (like picking numbers out of a hat) to be in 1 of 2 treatment arms. Neither participants nor the study doctor will be able to pick which treatment arm a participants enters. In Arm A, participants will receive navitoclax in combination with ruxolitinib. In Arm B, participants will receive the best available therapy (BAT) for MF. Adult participants with a diagnosis of MF that came back or did not get better after earlier treatment will be enrolled. Approximately 330 participants will be enrolled in approximately 210 sites across the world. In Arm A, participants will receive navitoclax tablet by mouth once daily with by mouth ruxolitinib tablet twice daily. In Arm B, participants will receive the BAT available to the investigator. Participants will receive the study drug until they experience no benefit (determined by the investigator), participants cannot tolerate the study drugs, or participants withdraw consent. The approximate treatment duration is about 3 years. There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at a hospital or clinic. The effect of treatment will be checked by medical assessments, blood and bone marrow tests, checking for side effects, and completing questionnaires.
Recruitment Criteria
Accepts Healthy Volunteers
Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms |
No |
Study Type
An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes. An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes. Searching Both is inclusive of interventional and observational studies. |
Interventional |
Eligible Ages | 18 Years and Over |
Gender | All |
Inclusion Criteria:
- - Must complete the Myelofibrosis Symptom Assessment Form (MFSAF) v4.0 on at least 4 out of the 7 days immediately prior to the date of randomization and must agree to collect MFSAF data daily by ePRO device during the study collection window.
- - Documented diagnosis of primary myelofibrosis (MF) as defined by the World Health Organization (WHO) classification, post polycythemia vera (PPV)-MF, or post essential thrombocytopenia (PET)-MF, characterized by bone marrow fibrosis grades 2 or 3.
- - Classified as intermediate-2 or high-risk MF, as defined by the Dynamic International Prognostic Scoring System Plus (DIPSS+).
- - Must currently be on treatment or have received prior treatment with a single Janus Kinase 2 (JAK2) inhibitor, ruxolitinib, and meet one of the following criteria (in addition to the minimum splenomegaly and symptom burden also required for eligibility): - Treatment with ruxolitinib for >= 24 weeks that was stopped due to lack of spleen response (refractory), or loss of spleen response or symptom control after a previous response (relapsed), or was continued despite relapsed/refractory status.
- - Treatment with ruxolitinib for < 24 weeks with documented disease progression while on therapy as defined by any of the following: - Appearance of new splenomegaly that is palpable to at least 5 cm below the left costal margin (LCM) in participants with no evidence of splenomegaly prior to the initiation of ruxolitinib.
- - A >= 100% increase in the palpable distance below the LCM in participants with measurable spleen distance 5 to 10 centimeters (cm) prior to the initiation of ruxolitinib.
- - A >= 50% increase in the palpable distance below the LCM in participants with measurable spleen distance > 10 cm prior to the initiation of ruxolitinib.
- - A spleen volume increase of >= 25% (as assessed by Magnetic Resonance Imaging [MRI] or Computed Tomography [CT] scan) in participants with a spleen volume assessment prior to the initiation of ruxolitinib.
- - Prior treatment with ruxolitinib of at least 10 mg twice daily (BID) for >= 28 days with intolerance defined as new RBC transfusion requirement (at least 2 units/month for 2 months) while receiving a total daily ruxolitinib dose of >= 30 mg but unable to reduce dose further due to lack of efficacy.
- - Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1, or 2.
- - Splenomegaly defined as palpable spleen measurement >= 5 cm below left costal margin or spleen volume >= 450 cm3 as assessed centrally by MRI or CT scan.
- - Baseline platelet count >= 100 × 10^9/L.
Exclusion Criteria:
- - Received prior treatment with a BH3-mimetic compound, bromodomain and extra-terminal (BET) inhibitor, or prior use of > 1 JAK2 inhibitor or stem cell transplant.
- - Eligible for stem cell transplantation at the time of study entry.
- - Receiving medication that interferes with coagulation or platelet function within 3 days prior to the first dose of study drug or during the study treatment period except for low dose aspirin (up to 100 mg daily) and low molecular weight heparin (LMWH).
- - Receiving anticancer therapy for an active malignancy or MF including chemotherapy, radiation therapy, hormonal therapy such that at least 5 half-lives of that medication is completed at least 7 days prior to the first dose of study drug or within 30 days prior to first dose of study drug, whichever is shorter, and during the study treatment period (other than any overlapping therapy as part of the selected BAT).
Trial Details
Trial ID:
This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries. |
NCT04468984 |
Phase
Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans. Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data. Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs. Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use. |
Phase 3 |
Lead Sponsor
The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data. |
AbbVie |
Principal Investigator
The person who is responsible for the scientific and technical direction of the entire clinical study. |
ABBVIE INC. |
Principal Investigator Affiliation | AbbVie |
Agency Class
Category of organization(s) involved as sponsor (and collaborator) supporting the trial. |
Industry |
Overall Status | Recruiting |
Countries | Australia, Austria, Belgium, Bulgaria, Canada, Croatia, Czechia, Denmark, France, Germany, Greece, Hungary, Israel, Italy, Japan, Korea, Republic of, New Zealand, Poland, Puerto Rico, Russian Federation, Serbia, South Africa, Spain, Sweden, Switzerland, Taiwan, Turkey, United Kingdom, United States |
Conditions
The disease, disorder, syndrome, illness, or injury that is being studied. |
Myelofibrosis (MF) |
Arms
Experimental: Arm A: Navitoclax + Ruxolitinib
Participants will receive navitoclax tablets once daily and ruxolitinib tablets twice daily.
Active Comparator: Arm B: Best Available Therapy (BAT)
Participants will receive one of the BAT options, per the investigator's discretion.
Interventions
Drug: - Navitoclax
Tablet; Oral
Drug: - Ruxolitinib
Tablet; Oral
Drug: - Best Available Therapy (BAT)
Tablet/Capsule; Oral or Solution for Subcutaneous Injection
Contact a Trial Team
If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.
Status
Completed
Address
Ironwood Cancer & Res Ctr /ID# 222162
Chandler, Arizona, 85224-5665
Status
Recruiting
Address
Highlands Oncology Group, PA /ID# 221826
Springdale, Arkansas, 72762
Status
Completed
Address
Moores Cancer Center at UC San Diego /ID# 219009
La Jolla, California, 92093
Status
Recruiting
Address
Long Beach Memorial Medical Ct /ID# 224542
Long Beach, California, 90806-1701
Status
Recruiting
Address
Icri /Id# 221967
Whittier, California, 90603
Status
Recruiting
Address
St. Mary's Hospital Regional Cancer Center /ID# 224229
Grand Junction, Colorado, 81501-6132
Status
Recruiting
Address
Augusta University Georgia Cancer Center /ID# 219051
Augusta, Georgia, 30912-0003
Status
Completed
Address
Columbus Regional Research Institute /ID# 224410
Columbus, Georgia, 31904-8915
Status
Recruiting
Address
Northwest Oncology & Hematology - Elk Grove Village /ID# 222818
Elk Grove Village, Illinois, 60007-3361
Status
Recruiting
Address
Loyola University Medical Ctr /ID# 219048
Maywood, Illinois, 60153
Status
Recruiting
Address
Indiana Blood & Marrow Transpl /ID# 221587
Indianapolis, Indiana, 46237
Status
Completed
Address
Tulane Medical Center - New Orleans /ID# 222940
New Orleans, Louisiana, 70112-2600
Status
Completed
Address
Ochsner Clinic Foundation-New Orleans /ID# 222777
New Orleans, Louisiana, 70121
Status
Recruiting
Address
American Oncology Partners of Maryland, PA /ID# 222836
Bethesda, Maryland, 20817
Status
Recruiting
Address
Dana-Farber Cancer Institute /ID# 218998
Boston, Massachusetts, 02215
Status
Recruiting
Address
University of Michigan /ID# 218463
Ann Arbor, Michigan, 48109
Status
Recruiting
Address
Henry Ford Health System /ID# 221190
Detroit, Michigan, 48202
Status
Recruiting
Address
William Beaumont Hospital /ID# 222705
Royal Oak, Michigan, 48073-6710
Status
Recruiting
Address
Saint Louis University Cancer Center /ID# 222287
Saint Louis, Missouri, 63110-2539
Status
Recruiting
Address
Summit Medical Group-Florham Park /ID# 222620
Florham Park, New Jersey, 07932-1049
Status
Recruiting
Address
Hackensack Univ Med Ctr /ID# 219047
Hackensack, New Jersey, 07601
Status
Recruiting
Address
The Cancer Institute at St. Francis Hospital /ID# 231782
Greenvale, New York, 11548-1219
Status
Recruiting
Address
Manhattan Hematology Oncology MHO Associates /ID# 223193
New York, New York, 10016-6028
Status
Recruiting
Address
Memorial Sloan Kettering Cancer Center-Koch Center /ID# 221081
New York, New York, 10065-6007
Status
Recruiting
Address
Wake Forest Baptist Medical Center /ID# 222899
Winston-Salem, North Carolina, 27157-0001
Status
Recruiting
Address
MetroHealth Medical Center /ID# 222650
Cleveland, Ohio, 44109
Status
Recruiting
Address
Hospital of the University of Pennsylvania /ID# 219001
Philadelphia, Pennsylvania, 19104-4238
Status
Completed
Address
Fox Chase Cancer Center /ID# 223955
Philadelphia, Pennsylvania, 19111
Status
Completed
Address
Houston Methodist Hospital /ID# 223103
Houston, Texas, 77030
Status
Completed
Address
University of Texas Health San Antonio MD Anderson Cancer Center /ID# 233942
San Antonio, Texas, 78229
Status
Recruiting
Address
Utah Cancer Specialists Salt Lake Clinic /ID# 221962
Salt Lake City, Utah, 84106
Status
Recruiting
Address
Virginia Cancer Specialists - Fairfax /ID# 223016
Fairfax, Virginia, 22031
Status
Completed
Address
Providence Everett /ID# 223130
Everett, Washington, 98201
Status
Recruiting
Address
Yakima Valley Memorial Hosp /ID# 224368
Yakima, Washington, 98902-6388
Status
Recruiting
Address
HSHS St. Vincent Hospital /ID# 224468
Green Bay, Wisconsin, 54301
International Sites
Status
Recruiting
Address
The Kinghorn Cancer Centre /ID# 221097
Darlinghurst, New South Wales, 2010
Status
Recruiting
Address
Border Medical Oncology Research Unit Albury Wodonga Regiona /ID# 223848
East Albury, New South Wales, 2640
Status
Recruiting
Address
Calvary Mater Newcastle /ID# 224324
Waratah, New South Wales, 2298
Status
Recruiting
Address
Alfred Health /ID# 221096
Melbourne, Victoria, 3004
Status
Recruiting
Address
Royal Perth Hospital /ID# 221099
Perth, Western Australia, 6000
Status
Recruiting
Address
Universitaetsklinikum St. Poelten /ID# 221709
Sankt Poelten, Niederoesterreich, 3100
Status
Recruiting
Address
Ordensklinikum Linz GmbH Elisabethinen /ID# 220914
Linz, Oberoesterreich, 4010
Status
Recruiting
Address
Klinikum Wels-Grieskirchen GmbH /ID# 220915
Wels, Oberoesterreich, 4600
Status
Recruiting
Address
Medizinische Universitaet Graz /ID# 220919
Graz, Steiermark, 8010
Status
Completed
Address
Medizinische Universitaet Wien /ID# 220911
Vienna, Wien, 1090
Status
Recruiting
Address
Hanusch Krankenhaus /ID# 220912
Wien, , 1140
Status
Recruiting
Address
ZNA Cadix /ID# 221468
Antwerp, Antwerpen, 2030
Status
Completed
Address
UCL Saint-Luc /ID# 224221
Woluwe-Saint-Lambert, Bruxelles-Capitale, 1200
Status
Recruiting
Address
Grand Hopital de Charleroi /ID# 224827
Charleroi, Hainaut, 6000
Status
Recruiting
Address
UZ Gent /ID# 220841
Gent, Oost-Vlaanderen, 9000
Status
Recruiting
Address
AZ-Delta /ID# 221469
Roeselare, West-Vlaanderen, 8800
Status
Recruiting
Address
Vitaz /Id# 228150
Sint-Niklaas, , 9100
Status
Recruiting
Address
UMHAT Alexandrovska EAD /ID# 231652
Sofiya, Sofia, 1431
Status
Recruiting
Address
UMHAT Dr Georgi Stranski EAD /ID# 231650
Pleven, , 5800
Status
Recruiting
Address
Acibadem City Clinic Tokuda University Hospital EAD /ID# 231649
Sofia, , 1407
Status
Recruiting
Address
UMHAT Sveti Ivan Rilski /ID# 231651
Sofia, , 1431
Status
Recruiting
Address
UMHAT Sveta Marina /ID# 234119
Varna, , 9010
Status
Recruiting
Address
Juravinski Cancer Centre /ID# 220887
Hamilton, Ontario, L8V 1C3
Status
Recruiting
Address
Ottawa Hospital Research Institute /ID# 238858
Ottawa, Ontario, K1H 8L6
Status
Recruiting
Address
Princess Margaret Cancer Centre /ID# 253942
Toronto, Ontario, M5G 2M9
Status
Recruiting
Address
CISSS-CA (Centre Integre de sante et de services sociaux de Chaudiere-Appalache) /ID# 222433
Levis, Quebec, G6V 3Z1
Status
Recruiting
Address
McGill University Health Center Research Institute /ID# 222614
Montreal, Quebec, H4A 3J1
Status
Recruiting
Address
Clinical Hospital Dubrava /ID# 230801
Zagreb, Grad Zagreb, 10000
Status
Recruiting
Address
Klinicka bolnica Merkur /ID# 230799
Zagreb, Grad Zagreb, 10000
Status
Active, not recruiting
Address
Klinicki bolnicki centar Zagreb /ID# 230798
Zagreb, Grad Zagreb, 10000
Status
Recruiting
Address
Klinicki Bolnicki Centar (KBC) Split - Firule /ID# 230800
Split, Splitsko-dalmatinska Zupanija, 21000
Status
Recruiting
Address
Klinicki bolnicki centar Osijek /ID# 231503
Osijek, , 31000
Status
Recruiting
Address
Fakultni nemocnice Brno /ID# 220959
Brno, , 613 00
Status
Completed
Address
Vseobecna fakultni nemocnice v Praze /ID# 220969
Praha, , 128 08
Status
Recruiting
Address
Aalborg University Hospital /ID# 224391
Aalborg, Nordjylland, 9000
Status
Recruiting
Address
Roskilde Sygehus /ID# 224456
Roskilde, Sjælland, 4000
Status
Recruiting
Address
Chu de Nice-Hopital L'Archet Ii /Id# 256291
Nice, Alpes-Maritimes, 06200
Status
Recruiting
Address
CHU NIMES - Hopital Caremeau /ID# 219128
Nimes CEDEX 9, Gard, 30029
Status
Recruiting
Address
CHU Bordeaux - Hopital Haut Leveque /ID# 222696
Pessac, Gironde, 33604
Status
Completed
Address
Hopital Avicenne - APHP /ID# 221287
Bobigny, Ile-de-France, 93000
Status
Completed
Address
CHU de Nantes, Hotel Dieu -HME /ID# 219127
Nantes, Pays-de-la-Loire, 44000
Status
Recruiting
Address
HCL - Hopital Lyon Sud /ID# 222695
Pierre Benite CEDEX, Rhone, 69495
Status
Recruiting
Address
Centre Hospitalier de CHAMBERY /ID# 223771
Chambery, Savoie, 73000
Status
Completed
Address
Chu Angers /Id# 219129
Angers, , 49933
Status
Recruiting
Address
AP-HP - Hopital Saint-Louis /ID# 221390
Paris, , 75010
Status
Recruiting
Address
Universitatsklinikum Mannheim /ID# 221529
Mannheim, Baden-Wuerttemberg, 68167
Status
Recruiting
Address
Stauferklinikum Schwaebisch Gmuend /ID# 223948
Mutlangen, Baden-Wuerttemberg, 73557
Status
Completed
Address
Gemeinschaftspraxis Dr. Heinrich und Prof. Bangerter /ID# 225025
Augsburg, Bayern, 86150
Status
Recruiting
Address
BAG Freiberg-Richter, Jacobasch, Illmer, Wolf /ID# 221346
Dresden, Sachsen, 01307
Status
Completed
Address
Augusta-Kranken-Anstalt gGmbH, Bochum-Mitte /ID# 224695
Bochum, , 44791
Status
Recruiting
Address
Klinikum Chemnitz gGmbH /ID# 224575
Chemnitz, , 09116
Status
Completed
Address
OncoResearch Lerchenfeld GmbH /ID# 225034
Hamburg, , 22081
Status
Recruiting
Address
Klinikum rechts der Isar /ID# 221526
Munich, , 81675
Status
Recruiting
Address
Universitaetsmedizin Rostock /ID# 224157
Rostock, , 18057
Status
Recruiting
Address
General Hospital of Athens Laiko /ID# 221175
Athens, Attiki, 11527
Status
Recruiting
Address
General Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 221179
Athens, , 10676
Status
Recruiting
Address
Olympion General Clinic SA /ID# 261423
Patras, , 26443
Status
Completed
Address
University General Hospital of Patras /ID# 221178
RION Patras Achaia, , 26504
Status
Recruiting
Address
General Hospital of Thessaloniki George Papanikolaou /ID# 221463
Thessaloniki, , 57010
Status
Recruiting
Address
Szegedi Tudomanyegyetem /ID# 220955
Szeged, Csongrad, 6720
Status
Recruiting
Address
Fejér Vármegyei Szent György Egyetemi Oktató Kórház /ID# 220949
Szekesfehervar, Fejer, 8000
Status
Recruiting
Address
Debreceni Egyetem Klinikai Kozpont /ID# 220947
Debrecen, Hajdu-Bihar, 4032
Status
Completed
Address
Somogy Varmegyei Kaposi Mor Oktato Korhaz /ID# 220948
Kaposvár, Somogy, 7400
Status
Recruiting
Address
Szabolcs-Szatmar-Bereg Varmegyei Oktatokorhaz /ID# 220946
Nyiregyhaza, Szabolcs-Szatmar-Bereg, 4400
Status
Completed
Address
Rambam Health Care Campus /ID# 219121
Haifa, H_efa, 3109601
Status
Recruiting
Address
The Lady Davis Carmel Medical Center /ID# 222973
Haifa, H_efa, 34362
Status
Recruiting
Address
Rabin Medical Center /ID# 219139
Haifa, H_efa, 4941492
Status
Recruiting
Address
Assuta Ashdod Medical Center /ID# 225281
Ashdod, HaDarom, 7747629
Status
Recruiting
Address
Assaf Harofeh Medical Center /ID# 222972
Zerifin, HaMerkaz, 70300
Status
Recruiting
Address
Galilee Medical Center /ID# 225280
Nahariya, HaTsafon, 2210001
Status
Recruiting
Address
The Chaim Sheba Medical Center /ID# 219136
Ramat Gan, Tel-Aviv, 5265601
Status
Recruiting
Address
Tel Aviv Sourasky Medical Center /ID# 219135
Tel Aviv, Tel-Aviv, 6423906
Status
Recruiting
Address
Hadassah Medical Center-Hebrew University /ID# 219111
Jerusalem, Yerushalayim, 91120
Status
Recruiting
Address
Hadassah Mt. Scopus /ID# 253394
Jerusalem, Yerushalayim, 9765400
Status
Recruiting
Address
Clalit Health Services - Emek Medical Center /ID# 220839
Afula, , 1834111
Status
Recruiting
Address
Azienda Ospedaliero Universitaria Ospedali Riuniti Do Ancona /ID# 238438
Torette, Ancona, 60020
Status
Recruiting
Address
Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Università Cattolica /ID# 219087
Rome, Lazio, 00168
Status
Recruiting
Address
ASST Monza/Ospedale San Gerardo /ID# 225113
Monza, Monza E Brianza, 20900
Status
Recruiting
Address
AOU Citta della Salute e della Scienza di Torino /ID# 221223
Torino, Piemonte, 10126
Status
Recruiting
Address
Azienda Ospedaliero-Universitaria Policlinico Umberto I /ID# 225731
Rome, Roma, 00161
Status
Recruiting
Address
Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII (Presidio Papa Giovanni /ID# 221222
Bergamo, , 24127
Status
Recruiting
Address
IRCCS Azienda Ospedaliero-Universitaria di Bologna /ID# 221077
Bologna, , 40138
Status
Recruiting
Address
A.O.U. Policlinico G. Rodolico S.Marco- Presidio G.Rodolico /ID# 219089
Catania, , 95123
Status
Recruiting
Address
Azienda Ospedaliero Universitaria Careggi /ID# 219090
Florence, , 50134
Status
Recruiting
Address
Azienda Ospedaliera Universitaria Federico II /ID# 224673
Napoli, , 80131
Status
Recruiting
Address
Azienda Ospedaliera Universitaria Paolo Giaccone /ID# 221078
Palermo, , 90127
Status
Recruiting
Address
Grande Ospedale Metropolitano Bianchi Melacrino Morelli /ID# 221220
Reggio Calabria, , 89124
Status
Recruiting
Address
Azienda Ospedaliera Universitaria Friuli Centrale/Presidio Ospedaliero Universit /ID# 221241
Udine, , 33100
Status
Recruiting
Address
ASST Sette Laghi /ID# 234183
Varese, , 21100
Status
Recruiting
Address
Azienda ULSS 8 Berica/Ospedale San Bortolo di Vicenza /ID# 221079
Vicenza, , 36100
Status
Recruiting
Address
Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital /ID# 221150
Nagoya-shi, Aichi, 453-8511
Status
Recruiting
Address
Fujita Health University /ID# 221598
Toyoake, Aichi, 470-1192
Status
Recruiting
Address
Aomori Prefectural Central Hospital /ID# 221778
Aomori-shi, Aomori, 030-8553
Status
Recruiting
Address
Chiba University Hospital /ID# 224546
Chiba-shi, Chiba, 260-8677
Status
Recruiting
Address
National Cancer Center Hospital East /ID# 226653
Kashiwa-shi, Chiba, 277-8577
Status
Recruiting
Address
Ehime University Hospital /ID# 221158
Toon-shi, Ehime, 791-0295
Status
Recruiting
Address
Kyushu University Hospital /ID# 221606
Fukuoka-shi, Fukuoka, 812-8582
Status
Recruiting
Address
Fukushima Medical University Hospital /ID# 221877
Fukushima-shi, Fukushima, 960-1295
Status
Recruiting
Address
Gifu University Hospital /ID# 224371
Gifu-shi, Gifu, 501-1194
Status
Recruiting
Address
Sapporo Hokuyu Hospital /ID# 221149
Sapporo-shi, Hokkaido, 003-0006
Status
Recruiting
Address
Kobe City Medical Center General Hospital /ID# 221156
Kobe-shi, Hyogo, 650-0047
Status
Recruiting
Address
Kanazawa University Hospital /ID# 223028
Kanazawa-shi, Ishikawa, 920-8641
Status
Recruiting
Address
Iwate Medical University Hospital /ID# 222044
Shiwa-gun, Iwate, 028-3695
Status
Recruiting
Address
Shonan Kamakura General Hospital /ID# 223030
Kamakura-shi, Kanagawa, 247-8533
Status
Recruiting
Address
Kumamoto Shinto General Hospital /ID# 255645
Kumamoto-shi, Kumamoto, 862-8655
Status
Recruiting
Address
Kyoto University Hospital /ID# 223008
Kyoto-shi, Kyoto, 606-8507
Status
Recruiting
Address
Mie University Hospital /ID# 221665
Tsu-shi, Mie, 514-8507
Status
Recruiting
Address
University of Miyazaki Hospital /ID# 221821
Miyazaki-shi, Miyazaki, 889-1692
Status
Recruiting
Address
Niigata University Medical & Dental Hospital /ID# 223034
Niigata-shi, Niigata, 951-8520
Status
Recruiting
Address
Kurashiki Central Hospital /ID# 221690
Kurashiki-shi, Okayama, 710-8602
Status
Recruiting
Address
Kansai Medical University Hospital /ID# 257289
Hirakata-shi, Osaka, 573-1191
Status
Recruiting
Address
Osaka University Hospital /ID# 221159
Suita-shi, Osaka, 565-0871
Status
Recruiting
Address
Dokkyo Medical University Saitama Medical Center /ID# 222334
Koshigaya-shi, Saitama, 343-8555
Status
Recruiting
Address
Juntendo University Shizuoka Hospital /ID# 221780
Izunokuni-shi, Shizuoka, 410-2295
Status
Recruiting
Address
Juntendo University Hospital /ID# 221154
Bunkyo-ku, Tokyo, 113-8431
Status
Recruiting
Address
Nippon Medical School Hospital /ID# 221676
Bunkyo-ku, Tokyo, 113-8602
Status
Recruiting
Address
The Institute of Medical Science the University of Tokyo Hospital /ID# 257944
Minato-ku, Tokyo, 108-8639
Status
Recruiting
Address
Tokyo Medical University Hospital /ID# 221540
Shinjuku-ku, Tokyo, 160-0023
Status
Recruiting
Address
Tokyo Metropolitan Bokutoh Hospital /ID# 254774
Sumida-ku, Tokyo, 130-8575
Status
Recruiting
Address
University of Yamanashi Hospital /ID# 221706
Chuo-shi, Yamanashi, 409-3821
Status
Recruiting
Address
The Catholic University of Korea, Seoul St. Marys Hospital /ID# 219061
Seoul, Seoul Teugbyeolsi, 06591
Status
Recruiting
Address
Pusan National University Hospital /ID# 220980
Busan, , 49241
Status
Recruiting
Address
Gachon University Gil Medical Center /ID# 220972
Incheon, , 21565
Status
Recruiting
Address
Seoul National University Hospital /ID# 219060
Seoul, , 03080
Status
Recruiting
Address
Samsung Medical Center /ID# 221091
Seoul, , 06351
Status
Recruiting
Address
Aotearoa Clinical Trials /ID# 232201
Papatoetoe, Auckland, 2025
Status
Recruiting
Address
Wojewodzkie Wielospecjalistyczne Centrum Onkologii I Traumatologii Im. M. Kopern /Id# 221161
Lodz, Lodzkie, 93-513
Status
Recruiting
Address
Samodzielny Publiczny Szpital Kliniczny Nr 1 w Lublinie /ID# 221124
Lublin, Lubelskie, 20-081
Status
Completed
Address
SP ZOZ Szpital Uniwersytecki w Krakowie /ID# 221160
Krakow, Malopolskie, 31-501
Status
Completed
Address
Lux Med Onkologia - Szpital Szamocka /Id# 221265
Warszawa, Mazowieckie, 01-748
Status
Recruiting
Address
MTZ Clinical Research Powered by Pratia /ID# 221759
Warszawa, Mazowieckie, 02-172
Status
Recruiting
Address
Uniwersyteckie Centrum Kliniczne /ID# 221298
Gdansk, Pomorskie, 80-214
Status
Recruiting
Address
ARS-MEDICAL Sp. z o.o. /ID# 238336
Pila, Wielkopolskie, 64-920
Status
Recruiting
Address
Szpital Kliniczny im. Heliodora Swiecickiego Uniwersytetu Medycznego im. Karola /ID# 241031
Poznan, Wielkopolskie, 60-569
Status
Completed
Address
Pratia Onkologia Katowice /ID# 224526
Katowice, , 40-519
Status
Recruiting
Address
Hospital del Centro Comprensivo de Cancer de la UPR /ID# 223281
San Juan, , 00927
Status
Active, not recruiting
Address
Moscow State budget healthcare /ID# 221116
Moscow, Moskva, 125284
Status
Completed
Address
Hospital n.a. V.V. Veresaev /ID# 225221
Moscow, , 127644
Status
Active, not recruiting
Address
Russian Research Institute of Hematology and Transfusiology of the FMBA /ID# 221115
Sankt-Peterburg, , 191024
Status
Active, not recruiting
Address
Almazov National Medical Research Centre /ID# 221114
Sankt-Peterburg, , 197341
Status
Completed
Address
Tula Regional Clinical Hospital /ID# 221302
Tula, , 300053
Status
Recruiting
Address
University Clinical Center Serbia /ID# 231058
Belgrade, Beograd, 11000
Status
Recruiting
Address
Clin Hosp Ctr Bezanijska Kosa /ID# 231059
Belgrade, Beograd, 11080
Status
Recruiting
Address
Clinical Center Vojvodina /ID# 231057
Novi Sad, Vojvodina, 21000
Status
Completed
Address
Wits Clinical Research Site /ID# 231554
Johannesburg, Gauteng, 2193
Status
Recruiting
Address
Alberts Cellular Therapy /ID# 231556
Pretoria, Gauteng, 0044
Status
Recruiting
Address
Hospital Clínico Universitario de Santiago-CHUS /ID# 221616
Santiago de Compostela, A Coruna, 15706
Status
Recruiting
Address
Hospital Universitario Central de Asturias /ID# 224815
Oviedo, Asturias, 33011
Status
Recruiting
Address
Hospital Universitario Germans Trias i Pujol /ID# 233727
Badalona, Barcelona, 08916
Status
Recruiting
Address
Hospital Universitario Dr. Negrin /ID# 220923
Las Palmas de Gran Canaria, Las Palmas, 35019
Status
Recruiting
Address
Hospital Universitario A Coruna - CHUAC /ID# 224617
A Coruna, , 15006
Status
Recruiting
Address
Hospital Parc de Salut del Mar /ID# 220922
Barcelona, , 08003
Status
Recruiting
Address
Hospital Universitario Vall d'Hebron /ID# 240979
Barcelona, , 08035
Status
Recruiting
Address
Hospital Universitario Virgen de las Nieves /ID# 253936
Granada, , 18014
Status
Recruiting
Address
Hospital Universitario 12 de Octubre /ID# 233726
Madrid, , 28041
Status
Recruiting
Address
Hospital Universitario La Paz /ID# 224813
Madrid, , 28046
Status
Completed
Address
Hospital Regional Universitario de Malaga /ID# 221906
Malaga, , 29011
Status
Completed
Address
Hospital Universitario de Salamanca /ID# 221904
Salamanca, , 37711
Status
Recruiting
Address
Hospital Universitario Virgen del Rocio /ID# 221932
Sevilla, , 41013
Status
Recruiting
Address
Hospital Clinico Universitario de Valencia /ID# 220920
Valencia, , 46010
Status
Recruiting
Address
Skane University Hospital Lund /ID# 220834
Lund, Skane Lan, 224 84
Status
Completed
Address
Universitätsspital Basel /ID# 221261
Basel, Basel-Stadt, 4031
Status
Completed
Address
Inselspital, Universitaetsspital Bern /ID# 223439
Bern, , 3010
Status
Recruiting
Address
Kaohsiung Chang Gung Memorial Hospital /ID# 218985
Kaohsiung City, Kaohsiung, 833
Status
Completed
Address
Kaohsiung Medical University Chung-Ho Memorial Hospital /ID# 218980
Kaohsiung, , 807
Status
Recruiting
Address
China Medical University Hospital /ID# 218979
Taichung, , 40447
Status
Recruiting
Address
Chi Mei Hospital - Liouying /ID# 221144
Tainan City, , 73657
Status
Recruiting
Address
Taipei Veterans General Hosp /ID# 221147
Taipei, , 11217
Status
Recruiting
Address
Linkou Chang Gung Memorial Hospital /ID# 218982
Taoyuan City, , 333
Status
Completed
Address
Gulhane Askeri Tip Academy /ID# 224568
Ankara, , 06010
Status
Recruiting
Address
Trakya University Medical Facu /ID# 224572
Edirne, Istanbul, , 22030
Status
Recruiting
Address
Ege University Medical Faculty /ID# 224570
Izmir, , 35040
Status
Recruiting
Address
Mersin University Medical /ID# 224571
Mersin, , 33343
Status
Recruiting
Address
Ondokuz mayis University Facul /ID# 224567
Samsun, , 55200
Status
Recruiting
Address
United Lincolnshire Hospitals NHS Trust /ID# 224613
Lincoln, Lincolnshire, LN2 4AX
Status
Recruiting
Address
Guys and St Thomas NHS Foundation Trust /ID# 221041
London, London, City Of, SE1 9RT
Status
Recruiting
Address
James Paget University Hospitals NHS Foundation Trust /ID# 221219
Great Yarmouth, Norfolk, NR31 6LA
Status
Recruiting
Address
University Hospitals Birmingham NHS Foundation Trust /ID# 221334
Birmingham, , B15 2TH
Status
Recruiting
Address
NHS Lothian /ID# 224378
Edinburgh, , EH3 9HE
Status
Recruiting
Address
The Newcastle Upon Tyne Hospitals NHS Foundation Trust /ID# 221335
Newcastle upon Tyne, , NE7 7DN