To Evaluate the Efficacy and Safety of Parsaclisib and Ruxolitinib in Participants With Myelofibrosis (LIMBER-313)
Study Purpose
The purpose of the study is to compare the efficacy of parsaclisib when combined with ruxolitinb versus placebo combined with ruxolitinib in participants with myelofibrosis.
Recruitment Criteria
Accepts Healthy Volunteers
Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms |
No |
Study Type
An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes. An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes. Searching Both is inclusive of interventional and observational studies. |
Interventional |
Eligible Ages | 18 Years and Over |
Gender | All |
Inclusion Criteria:
- - Diagnosis of PMF, PPV-MF, or PET-MF.
- - DIPSS risk category of intermediate-1, intermediate-2, or high.
- - Palpable spleen of ≥ 5 cm below the left costal margin on physical examination at the screening visit.
- - Active symptoms of MF at the screening visit, as demonstrated by the presence of a TSS of ≥ 10 using the Screening Symptom Form.
- - Participants with an ECOG performance status score of 0, 1, or 2.
- - Screening bone marrow biopsy specimen and pathology report(s) available that was obtained within the prior 2 months or willingness to undergo a bone marrow biopsy at screening/baseline; willingness to undergo bone marrow biopsy at Week 24 and every 24 weeks there after.
- - Life expectancy of at least 24 weeks.
- - Willingness to avoid pregnancy or fathering children.
Exclusion Criteria:
- - Prior use of any JAK inhibitor.
- - Prior therapy with any drug that inhibits PI3K (examples of drugs targeting this pathway include but are not limited to INCB040093, idelalisib, duvelisib, buparlisib, copanlisib, and umbralisib).
- - Use of experimental drug therapy for MF or any other standard drug (eg, danazol, hydroxyurea) used for MF within 3 months of starting study drug and/or lack of recovery from all toxicities from previous therapy to ≤ Grade 1.
- - Inability to swallow food or any condition of the upper gastrointestinal tract that precludes administration of oral medications.
- - Recent history of inadequate bone marrow reserve.
- - Inadequate liver and renal function at screening.
- - Active bacterial, fungal, parasitic, or viral infection that requires therapy.
- - Active HBV or HCV infection that requires treatment or at risk for HBV reactivation.
- - Known HIV infection.
- - Uncontrolled, severe, or unstable cardiac disease that in the investigator's opinion may jeopardize the safety of the participant or compliance with the Protocol.
- - Active invasive malignancy over the previous 2 years.
- - Splenic irradiation within 6 months before receiving the first dose of study drug.
- - Concurrent use of any prohibited medications.
- - Active alcohol or drug addiction that would interfere with the ability to comply with the study requirements.
- - Use of any potent CYP3A4 inhibitors or inducers within 14 days or 5 half lives(whichever is longer) before the first dose of study drug or anticipated during the study.
- - Inadequate recovery from toxicity and/or complications from a major surgery before starting therapy.
- - Currently breastfeeding or pregnant.
- - Any condition that would, in the investigator's judgment, interfere with full participation in the study, including administration of study drug and attending required study visits; pose a significant risk to the participant; or interfere with interpretation of study data.
- - History of Grade 3 or 4 irAEs from prior immunotherapy.
Trial Details
Trial ID:
This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries. |
NCT04551066 |
Phase
Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans. Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data. Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs. Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use. |
Phase 3 |
Lead Sponsor
The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data. |
Incyte Corporation |
Principal Investigator
The person who is responsible for the scientific and technical direction of the entire clinical study. |
Albert Assad, M.D |
Principal Investigator Affiliation | Incyte Corporation |
Agency Class
Category of organization(s) involved as sponsor (and collaborator) supporting the trial. |
Industry |
Overall Status | Recruiting |
Countries | Austria, Belgium, China, Denmark, Finland, France, Germany, Israel, Italy, Japan, Korea, Republic of, Norway, Poland, Spain, Turkey, United Kingdom, United States |
Conditions
The disease, disorder, syndrome, illness, or injury that is being studied. |
Myelofibrosis, Primary Myelofibrosis, Post Essential Thrombocythemia Myelofibrosis, Post Polycythemia Vera Myelofibrosis |
Study Website: | View Trial Website |
This is a Phase 3, randomized, double-blind study of the combination of the PI3Kδ inhibitor parsaclisib or matching placebo and the JAK1/2 inhibitor ruxolitinib in participants with PMF or secondary MF (PPV-MF or PET-MF) with DIPSS risk category of intermediate or high. Prospective participants must have not received prior MF therapy with a JAK inhibitor or a PI3K inhibitor. After participants have been determined to be eligible for the study and completed the baseline symptom diary assessment for 7 days, they will be randomized to 1 of 2 treatment groups, with stratification for platelet count (≥ 100 × 10^9/L vs.#46;50 to < 100 × 10^9/L inclusive) and DIPSS risk category (high vs.#46;intermediate-2 vs.#46;intermediate-1). Once all enrolled participants completed the week 24 assessments the study will be unblinded and and participants randomized to placebo will have the opportunity to cross over to begin receiving parsaclisib, together with continued ruxolitinib, as long as hematology parameters are adequate.
Arms
Experimental: Group A : parsaclisib + ruxolitinib
Participants will receive parsaclisib and ruxolitinib starting from Day 1 for the duration of study, ruxolitinib dose will be determined by baseline platelet count.
Placebo Comparator: Group B : placebo + ruxolitinib
Participants will receive placebo and ruxolitinib starting from Day 1 for the duration of study, ruxolitinib dose will be determined by baseline platelet count.
Interventions
Drug: - parsaclisib
parsaclisib will be administered QD orally
Drug: - ruxolitinib
ruxolitinib will be administered BID orally
Drug: - placebo
placebo will be administered QD orally
Contact a Trial Team
If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.
Status
Recruiting
Address
Alaska Oncology and Hematology
Anchorage, Alaska, 99508
Status
Recruiting
Address
Mayo Clinic Rochester
Phoenix, Arizona, 85054
Status
Recruiting
Address
Sutter Health Alta Bates Summit Medical Center Absmc Alta Bates Summit Comprehensive Cancer Center
Berkeley, California, 94704
Status
Recruiting
Address
CCARE
Fresno, California, 93720
Status
Recruiting
Address
California Research Institute (Cri)
Los Angeles, California, 90027-6005
Status
Recruiting
Address
UCLA School of Medicine
Los Angeles, California, 90095-3075
Status
Recruiting
Address
Scripps Clinic
San Diego, California, 92103
Status
Recruiting
Address
Coastal Integrated Cancer Care-Cicc
San Luis Obispo, California, 93401
Status
Recruiting
Address
Stamford Hospital-Medical Oncology Hematology
Stamford, Connecticut, 06904
Status
Not yet recruiting
Address
Georgetown University
Washington, District of Columbia, 20057
Status
Recruiting
Address
Emory University
Atlanta, Georgia, 30322
Status
Recruiting
Address
University of Kansas Hospital Authority
Westwood, Kansas, 66205
Status
Recruiting
Address
University of Kentucky-Markey Cancer Center
Lexington, Kentucky, 40536
Status
Recruiting
Address
Tulane University
New Orleans, Louisiana, 70112
Status
Recruiting
Address
Johns Hopkins University
Baltimore, Maryland, 21287
Status
Not yet recruiting
Address
Massachusetts General Hospital
Boston, Massachusetts, 02114
Status
Recruiting
Address
Midamerica Cancer Care
Kansas City, Missouri, 64114
Status
Recruiting
Address
New Jersey Hematology Oncology Associates Llc
Brick, New Jersey, 08724
Status
Recruiting
Address
Morristown Medical Center-Atlantic Health System
Morristown, New Jersey, 07960
Status
Recruiting
Address
Montefiore Medical Center
Bronx, New York, 10467
Status
Recruiting
Address
Roswell Park Cancer Institute
Buffalo, New York, 14263
Status
Not yet recruiting
Address
Westchester Medical Center Advanced Oncology and Infusion Center
Hawthorne, New York, 10532
Status
Recruiting
Address
Mount Sinai School of Medicine
New York, New York, 10029
Status
Not yet recruiting
Address
Memorial Sloan Kettering Cancer Center
New York, New York, 10065
Status
Recruiting
Address
Duke Cancer Center
Durham, North Carolina, 27710
Status
Recruiting
Address
Wake Forest Baptist Medical Center
Winston-Salem, North Carolina, 27157
Status
Not yet recruiting
Address
Ohio State University
Columbus, Ohio, 43210
Status
Recruiting
Address
Kaiser Permanente-Northwest
Portland, Oregon, 97227
Status
Recruiting
Address
Oregon Health & Science University
Portland, Oregon, 97239
Status
Recruiting
Address
Avera Cancer Institute
Sioux Falls, South Dakota, 57103
Status
Recruiting
Address
Texas Oncology-Baylor Sammons Cancer Center
Dallas, Texas, 75246-2092
Status
Recruiting
Address
Kelsey Seybold Clinic
Houston, Texas, 77025
Status
Recruiting
Address
Houston Methodist Hospital
Houston, Texas, 77030
Status
Recruiting
Address
Renovatio Clinical
Spring, Texas, 77380
Status
Recruiting
Address
Providence Regional Medical Center Everett
Everett, Washington, 98201
Status
Recruiting
Address
Seattle Cancer Care Alliance
Seattle, Washington, 98109
International Sites
Status
Recruiting
Address
Ordensklinikum Linz Gmbh Elisabethinen
Linz, , 04020
Status
Recruiting
Address
Universitaetsklinikum St. Poelten
Saint P�LTEN, , 03100
Status
Recruiting
Address
Hanusch-Krankenhaus Der Wiener Gebietskrankenkasse
Wien, , 01140
Status
Recruiting
Address
Hanusch-Krankenhaus Wiener Gebietskrankenkasse
Wien, , 01140
Status
Recruiting
Address
A.Z. St.-Jan A.V.
Brugge, , 08000
Status
Recruiting
Address
Cliniques Universitaires Ucl Saint-Luc
Brussels, , 01000
Status
Recruiting
Address
Grand Hospital de Charleroi
Charleroi, , 06000
Status
Recruiting
Address
Jessa Ziekenhuis
Hasselt, , 03500
Status
Recruiting
Address
AZ DELTA
Roeselare, , 08800
Status
Not yet recruiting
Address
Affiliated Hospital of Hebei University
Baoding, , 71000
Status
Recruiting
Address
Peking University People'S Hospital (Pkuph) - Institute of Hematology
Beijing SHI, , 100044
Status
Recruiting
Address
Peking University Third Hospital
Beijing, , 100091
Status
Recruiting
Address
The First Hospital of Jilin University
Changchun, , 130021
Status
Recruiting
Address
Xiangya Hospital Central South University
Changsha, , 410008
Status
Recruiting
Address
Fujian Medical University Union Hospital
Fuzhou, , 350001
Status
Recruiting
Address
Guangdong Provincial of People Hospital
Guangzhou, , 510080
Status
Recruiting
Address
Nanfang Hospital
Guangzhou, , 510515
Status
Recruiting
Address
The First Affiliated Hospital of Zhejiang University
Hangzhou, , 310003
Status
Recruiting
Address
Harbin Institute of Hematology and Oncology
Harbin, , 150010
Status
Recruiting
Address
Anhui Provincial Hospital
Hefei, , 230001
Status
Recruiting
Address
The Affiliated Hospital of Inner Mongolia Medical University
Hohhot, , 10050
Status
Recruiting
Address
Jinan Central Hospital
Jinan, , 250013
Status
Not yet recruiting
Address
The First Hospital of Lanzhou University
Lanzhou, , 730000
Status
Recruiting
Address
Lanzhou University Second Hospital
Lanzhou, , 730030
Status
Recruiting
Address
Jiangxi Provincial of People Hospital
Nanchang, , 330000
Status
Not yet recruiting
Address
The First Affiliated Hospital of Nanchang University
Nanchang, , 330006
Status
Not yet recruiting
Address
Jiangsu Province Hospital
Nanjing, , 210029
Status
Not yet recruiting
Address
Zhongshan Hospital Fudan University
Shanghai, , 200032
Status
Recruiting
Address
Shenzhen University Hospital
Shenzhen, , 518055
Status
Recruiting
Address
The Second Hospital of Hebei Medical University
Shijiazhuang, , 50000
Status
Recruiting
Address
Tianjin Medical University General Hospital
Tianjin, , 300052
Status
Recruiting
Address
The First Affiliated Hospital of Wenzhou Medical University
Wenzhou, , 325000
Status
Recruiting
Address
Union Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology
Wuhan, , 430022
Status
Recruiting
Address
Yantai Yuhuangding Hospital
Yantai, , 264000
Status
Not yet recruiting
Address
Henan Provincial Peoples Hospital
Zhengzhou, , 450003
Status
Recruiting
Address
Aalborg University Hospital
Aalborg, , 09000
Status
Recruiting
Address
Odense University Hospital
Odense, , 05000
Status
Recruiting
Address
Helsinki University Central Hospital
Helsinki, , FI-00029
Status
Recruiting
Address
Centre Hospitalier Universitaire Grenoble Alpes (Chu Grenoble Alpes) - Hopital Albert Michallon
La Tronche, , 38700
Status
Recruiting
Address
Centre Hospitalier de Versailles - Hopital Andre Mignot
LE Chesnay-rocquencourt, , 78157
Status
Recruiting
Address
Chu Limoges - Hopital Dupuytren
Limoges, , 87042
Status
Recruiting
Address
Centre Hospitalier Universitaire de Nantes (Chu de Nantes) - Hotel-Dieu
Nantes, , 44093
Status
Recruiting
Address
Ap-Hp Groupe Hospitalier Saint-Louis Lariboisiere Fernand-Widal Site Saint Louis (Paris)
Paris, , 75010
Status
Recruiting
Address
Hospices Civils de Lyon Centre Hospitalier Lyon Sud
Pierre-benite, , 69495
Status
Recruiting
Address
Hospital de La Miletrie
Poitiers, , 86021
Status
Recruiting
Address
Chu de Rennes - Hospital Pontchaillou
Rennes, , 35033
Status
Not yet recruiting
Address
Centre Hospitalier de Roubaix
Roubaix, , 59100
Status
Recruiting
Address
Universitatsklinikum Halle (Saale)
Halle (saale), , 06120
Status
Not yet recruiting
Address
Klinikum Kassel Gmbh
Kassel, , 34125
Status
Not yet recruiting
Address
Universitatsklinikum Magdeburg A.O.R.
Magdeburg, , 39120
Status
Recruiting
Address
Universitaetsmedizin Rostock
Rostock, , 18057
Status
Recruiting
Address
Shamir Medical Center Formerly Assaf Harofeh Medical Center
Beer Yaaqov, , 70300
Status
Not yet recruiting
Address
Rambam Health Care Campus
Haifa, , 31999
Status
Recruiting
Address
Hadassah Hebrew University Medical Center Ein Karem Hadassah
Jerusalem, , 91120
Status
Recruiting
Address
Davidoff Cancer Center Rabin Medical Center
Petah-tikva, , 49100
Status
Recruiting
Address
Kaplan Medical Center
Rehovot, , 76100
Status
Recruiting
Address
Tel Aviv Sourasky Medical Center
Tel Aviv-yafo, , 64239
Status
Recruiting
Address
Assuta Ramat Hahayal
Tel Aviv, , 69710
Status
Recruiting
Address
Lstituto Di Ematologia Lorenzo Ea.Seragnoli Universita Degli Studi Di Bologna - Policlinico S. Or
Bologna, , 40138
Status
Recruiting
Address
Azienda Policlinico Vittorio Emanuele
Catania, , 95123
Status
Recruiting
Address
Universita Degli Studi Di Genova - Facolta Di Medicina E Chirurgia
Genova, , 16132
Status
Recruiting
Address
Istituto Romagnolo Per Lo Studio Dei Tumori Dino Amadori
Meldola, , 47014
Status
Recruiting
Address
Fondazione Irccs Ca Granda Ospedale Maggiore
Milano, , 20122
Status
Recruiting
Address
Istituto Di Ricovero E Cura A Carattere Scientifico (Irccs) Ospedale San Raffaele
Milan, , 20132
Status
Recruiting
Address
Universita Di Napoli Federico Ii
Napoli, , 80131
Status
Not yet recruiting
Address
Azienda Ospedaliera Ospedali Riuniti Villa Sofia - Cervello
Palermo, , 90146
Status
Recruiting
Address
Aormn Hospital Hematology and Bmt Center
Pesaro, , 61122
Status
Recruiting
Address
Grande Ospedale Metropolitano Bianchi-Melacrino-Morelli
Reggio Calabria, , 89133
Status
Recruiting
Address
Universita Di Roma Tor Vergata
Roma, , 00133
Status
Recruiting
Address
Universita Di Roma
Roma, , 00161
Status
Recruiting
Address
Policlinico Universitario Agostino Gemelli Universita Cattolica Del Sacro Cuore
Roma, , 00168
Status
Recruiting
Address
Policlinico Universitario Agostino Gemelli Universita Cattolica Del Sacro Cuore
Rome, , 00168
Status
Recruiting
Address
Aou San Giovanni Di Dio E Ruggi D'Aragona
Salerno, , 84131
Status
Recruiting
Address
Azienda Ospedaliera San Giuseppe Moscati
Taranto, , 74123
Status
Recruiting
Address
Azienda Sanitaria Universitaria Friuli Centrale Asu Fc
Udine, , 33100
Status
Recruiting
Address
A.O. Universitaria Ospedale Di Circolo E Fondazione Macchi
Varese, , 21100
Status
Recruiting
Address
Azienda Ospedaliera Universitaria Integrata Verona (Ospedale Borgo Roma)
Verona, , 37134
Status
Recruiting
Address
Chiba Cancer Center
Chiba, , 260-8677
Status
Recruiting
Address
University of Yamanashi Hospital
Chuo, , 409-3898
Status
Recruiting
Address
Kyushu University Hospital
Fukuoka, , 812-8582
Status
Recruiting
Address
Japanese Red Cross Society Himeji Hospital
Himeji-shi, , 670-8540
Status
Recruiting
Address
Kansai Medical University Hospital
Hirakata, , 573-1191
Status
Recruiting
Address
Tokai University Hospital
Isehara, , 2591193
Status
Recruiting
Address
Kagoshima University Hospital
Kagoshima-shi, , 890-8520
Status
Recruiting
Address
Hospital of the University of Occupation and Environmental Health
Kitakyushu-shi, , 807-8556
Status
Recruiting
Address
Kobe City Medical Center General Hospital
Kobe-shi, , 650-0047
Status
Not yet recruiting
Address
Kumamoto Shinto General Hospital
Kumamoto-shi, , 862-8655
Status
Recruiting
Address
University of Miyazaki Hospital
Miyazaki, , 889-1692
Status
Recruiting
Address
Japanese Red Cross Nagoya Daini Hospital
Nagoya-shi, , 453-8511
Status
Recruiting
Address
Ogaki Municipal Hospital
Ogaki, , 5038502
Status
Recruiting
Address
Osaka Metropolitan University Hospital
Osaka, , 545-8585
Status
Recruiting
Address
Dokkyo Medical University Saitama Medical Center
Saitama, , 343-8555
Status
Recruiting
Address
Hokuyukai Sapporo Hokuyu Hospital
Sapporo, , 003-0006
Status
Recruiting
Address
Tohoku University Hospital
Sendai, , 980-8574
Status
Recruiting
Address
Juntendo University Hospital
Tokyo, , 113-8431
Status
Not yet recruiting
Address
Nippon Medical School Hospital
Tokyo, , 113-8603
Status
Recruiting
Address
Mie University Hospital
TSU, , 514-0001
Status
Recruiting
Address
Yokohama Municipal Citizens Hospital
Yokohama-shi, , 221-0855
Status
Recruiting
Address
Seoul National University Hospital
Seoul, , 03080
Status
Recruiting
Address
Samsung Medical Center
Seoul, , 03651
Status
Recruiting
Address
THE CATHOLIC UNIVERSITY OF KOREA SEOUL ST. MARY�S HOSPITAL
Seoul, , 06591
Status
Recruiting
Address
Wonju Severance Christian Hospital
Wonju, , 26426
Status
Recruiting
Address
Haukeland University Hospital
Bergen, , 05021
Status
Recruiting
Address
Akershus University Hospital
L�RENSKOG, , 01478
Status
Not yet recruiting
Address
Uniwersyteckie Centrum Kliniczne
Gdansk, , 80-214
Status
Not yet recruiting
Address
Samodzielny Publiczny Szpital Kliniczny Im. Andrzeja Mielckiego
Katowice, , 40-027
Status
Recruiting
Address
Pratia Hematologia Katowice
Katowice, , 41-519
Status
Recruiting
Address
Sp Zoz Szpital Uniwersytecki
Krakow, , 31-501
Status
Recruiting
Address
Samodzielny Publiczny Szpital Kliniczny Nr 1
Lublin, , 20-081
Status
Recruiting
Address
Institute of Hematology and Transfusion Medicine
Warszawa, , 02-776
Status
Not yet recruiting
Address
Hospital General Unviersitario de Alicante
Alicante, , 3010
Status
Recruiting
Address
Ico Hospital Germans Trias I Pujol
Badalona, , 08916
Status
Recruiting
Address
Hospital Del Mar
Barcelona, , 08003
Status
Recruiting
Address
Hospital General Universitario Vall D Hebron
Barcelona, , 08035
Status
Recruiting
Address
Ico-Hospital Duran I Reynals
Barcelona, , 08908
Status
Recruiting
Address
Institut Catala Doncologia Ico - Hospital Duran I Reynals Location
Barcelona, , 08908
Status
Recruiting
Address
Ico Hospital Germans Trias I Pujol
Barcelona, , 08916
Status
Recruiting
Address
Hospital de Basurto
Bilbao, , 48013
Status
Recruiting
Address
Hospital Universitario Virgen de La Arrixaca
El Palmar, , 30120
Status
Recruiting
Address
Hospital Universitario Virgen de Las Nieves
Granada, , 18014
Status
Recruiting
Address
Hospital Universitario Insular de Gran Canaria
Las Palmas de Gran Canaria, , 35010
Status
Recruiting
Address
Fundacian Jimnez Diaz
Madrid, , 28040
Status
Recruiting
Address
Hospital Universitario 12 de Octubre
Madrid, , 28041
Status
Recruiting
Address
Hospital General Universitario Morales Meseguer
Murcia, , 30008
Status
Recruiting
Address
Hospital Clinico Universitario de Salamanca
Salamanca, , 37007
Status
Recruiting
Address
Hospital Universitari I Politecnic La Fe
Valencia, , 46000
Status
Recruiting
Address
Hospital Universitario Doctor Peset
Valencia, , 46017
Status
Not yet recruiting
Address
Baskent University Adana Hospital
Adana, , 01250
Status
Recruiting
Address
Gazi University Hospital Gazi University Faculty of Medicine
Ankara, , 06500
Status
Recruiting
Address
Istanbul Medipol Universitesi Ibagcilar Medipol Mega Universitesi Hastanesi
Istanbul, , 34214
Status
Not yet recruiting
Address
Baskent University Istanbul Hospital
Istanbul, , 34662
Status
Recruiting
Address
Ege University Hospital
Izmir, , 35040
Status
Not yet recruiting
Address
Dokuz Eylul University
Izmir, , 35340
Status
Not yet recruiting
Address
Ondokuz Mayis University Medicine Faculty
Samsun, , 55200
Status
Recruiting
Address
United Lincolnshire Hospitals
Boston, , PE21 9QS
Status
Recruiting
Address
Gloucestershire Royal Hospital
Gloucester, , GL1 3NN
Status
Not yet recruiting
Address
Barts Health Nhs Trust - St Bartholomews Hospital
London, , EC1A 7BE
Status
Recruiting
Address
University College London Hospitals Nhs Foundation Trust
London, , NW1 2BU
Status
Recruiting
Address
Sheffield Teaching Hospitals Nhs Foundation Trust - Weston Park Hospital
Sheffield, , S5 7AT
Status
Recruiting
Address
University Hospital of North Midlands Nhs Trust
Stoke-on-trent, , ST4 6QG