An Efficacy and Safety Study of Luspatercept (ACE-536) Versus Placebo in Subjects With Myeloproliferative Neoplasm-Associated Myelofibrosis on Concomitant JAK2 Inhibitor Therapy and Who Require Red Blood Cell Transfusions
Study Purpose
The purpose of this Phase 3 study is to evaluate the efficacy and safety of Luspatercept compared with placebo in subjects with myeloproliferative neoplasm (MPN)-associated Myelofibrosis (MF) and anemia on concomitant Janus kinase 2 (JAK2) inhibitor therapy and who require red blood cell count (RBC) transfusions. The study is divided into Screening Period, a Treatment Phase (consisting of a Blinded Core Treatment Period, a Day 169 Response Assessment, a Blinded Extension Treatment Period, and an Open-label Extension Treatment Period), and a Posttreatment Follow-up Period. Following the Day 169 Response Assessment, subjects who did not show clinical benefit will have the option to unblind. Subjects who were on placebo during the Blinded Core Treatment Period will have the opportunity to crossover into the Open-Label Extension Treatment Period and receive Luspatercept.
Recruitment Criteria
Accepts Healthy Volunteers
Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms |
No |
Study Type
An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes. An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes. Searching Both is inclusive of interventional and observational studies. |
Interventional |
Eligible Ages | 18 Years and Over |
Gender | All |
Inclusion Criteria:
Subjects must satisfy the following criteria to be randomized in the study: 1. Subject is ≥18 years of age at the time of signing the ICF. 2. Subject has a diagnosis of PMF according to the 2016 World Health Organization (WHO) criteria or diagnosis of post-ET or post-PV MF according to the IWG-MRT 2007 criteria , confirmed by the most recent local pathology report. 3. Subject is requiring RBC transfusions as defined as: a. Average RBC-transfusion frequency: 4 to 12 RBC units/12 weeks immediately up to randomization. There must be no interval > 6 weeks (42 days) without ≥ 1 RBC transfusion. b. RBC transfusions are scored in determining eligibility when given for treatment of:- - Symptomatic (ie, fatigue or shortness of breath) anemia with a pretransfusion Hgb ≤ 9.5 g/dL or.
- - Asymptomatic anemia with a pretransfusion Hgb ≤ 7 g/dL c.
Exclusion Criteria:
The presence of any of the following will exclude a subject from randomization: 1. Subject with anemia from cause other than MPN-associated MForJAK2 inhibitor therapy (eg, iron deficiency, vitamin B12 and/or folate deficiencies, autoimmune or hemolytic anemia, infection, or any type of known clinically significant bleeding or sequestration). 2. Subject use of hydroxyurea, immunomodulatory compounds such as pomalidomide, thalidomide, ESAs, androgenic steroids or other drugs with potential effects on hematopoiesis ≤ 8 weeks immediately up to the date of randomization. 1. Systemic corticosteroids are permitted for nonhematological conditions providing the subject is receiving a constant dose equivalent to ≤ 10 mg prednisone for the 4 weeks immediately up to randomization. 2. Iron chelation therapy (ICT) is permitted providing the subject is receiving a stable dose for the 8 weeks immediately up to randomization. 3. Subject with any of the following laboratory abnormalities at screening: 1. Neutrophils: < 1 x 10^9/L. 2. White blood count (WBC): > 100 x 10^9/L. 3. Platelets: the lowest allowable level as approved for the concomitant JAK2 inhibitor but not < 25 x 10^9/L or > 1000 x 10^9/L. 4. Peripheral blood myeloblasts:> 5% 5. Estimated glomerular filtration rate:< 30 mL/min/1.73 m2 (via the 4-variable modification of diet in renal disease [MDRD] formula) or nephrotic subjects (eg, urine albumin-to-creatinine ratio > 3500 mg/g) 6. Aspartate aminotransferase (AST) or alanine aminotransferase (ALT):> 3.0 x upper limit of normal (ULN) 7. Direct bilirubin: ≥ 2 x ULN.- - Higher levels are acceptable if these can be attributed to active red blood cell precursor destruction within the bone marrow (eg, ineffective erythropoiesis) 4.
Trial Details
Trial ID:
This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries. |
NCT04717414 |
Phase
Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans. Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data. Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs. Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use. |
Phase 3 |
Lead Sponsor
The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data. |
Celgene |
Principal Investigator
The person who is responsible for the scientific and technical direction of the entire clinical study. |
Bristol-Myers Squibb |
Principal Investigator Affiliation | Bristol-Myers Squibb |
Agency Class
Category of organization(s) involved as sponsor (and collaborator) supporting the trial. |
Industry |
Overall Status | Recruiting |
Countries | Argentina, Australia, Austria, Belgium, Canada, Chile, China, Colombia, Czechia, France, Germany, Greece, Hong Kong, Hungary, Ireland, Israel, Italy, Japan, Korea, Republic of, Lebanon, Poland, Puerto Rico, Romania, Russian Federation, Spain, United Kingdom, United States |
Conditions
The disease, disorder, syndrome, illness, or injury that is being studied. |
Myeloproliferative Disorders, Myelofibrosis, Primary Myelofibrosis, Post-Polycythemia Vera Myelofibrosis, Anemia |
Study Website: | View Trial Website |
Permitted Concomitant Medications and Procedures.
- - Subjects are receiving a JAK2 inhibitor for the treatment of MPN-associated MF that is approved in the country where the study is being conducted.
- - Best supportive care (BSC) includes, but is not limited to, treatment with transfusions (eg, RBC, platelet, whole blood), ICTs, antibiotic, antiviral and/or antifungal therapy, and nutritional support as needed.
- - Granulocyte colony-stimulating factors (ie, G-CSF, granulocyte macrophage colony-stimulating factor [GM-CSF]) are allowed only in cases of neutropenic fever or as clinically indicated per product label.
- - Prophylactic antithrombotic therapy is permitted.
- - Thrombopoietin and platelet transfusions are permitted.
- - Treatment with systemic corticosteroids is permitted for nonhematological conditions providing the subject is receiving a constant dose equivalent to ≤ 10 mg prednisone during the study.
- - Administration of attenuated vaccines (eg, influenza vaccine) is allowed if clinically indicated per Investigator discretion.
- - Iron chelation therapy (ICT) is to be used according to the product label.
- - Cytotoxic, chemotherapeutic, targeted, or investigational agents/therapies (excluding JAK2 inhibitor therapy) - Azacitidine, decitabine, or other hypomethylating agents.
- - Lenalidomide, thalidomide, and pomalidomide.
- - Erythropoietin stimulating agents (ESAs) and other RBC hematopoietic growth factors (eg, IL-3) - Hydroxyurea or other alkylating agents.
- - Androgens (unless given to treat hypogonadism) - Oral retinoids (topical retinoids are permitted) - Arsenic trioxide.
- - Interferon.
- - Anagrelide.
- - Systemic corticosteroids at a dose equivalent to > 10 mg prednisone.
Arms
Experimental: Experimental Arm: Luspatercept (ACE-536)
Luspatercept will be given to participants via subcutaneous injection (administered on Day 1 of each 21-day treatment cycle)
Placebo Comparator: Control Arm: Placebo
Placebo starting dose with volume equivalent to experimental arm subcutaneous injection every 3 weeks (administered on Day 1 of each 21-day treatment cycle)
Interventions
Drug: - ACE-536
Subcutaneous Injection
Other: - Placebo
Subcutaneous Injection
Contact a Trial Team
If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.
Status
Withdrawn
Address
University Of California San Diego
La Jolla, California, 92037
Status
Recruiting
Address
University Of California Los Angeles
Los Angeles, California, 90095
Status
Not yet recruiting
Address
Medical Oncology Associates - Sd
San Diego, California, 92123
Status
Not yet recruiting
Address
Baptist MD Anderson Cancer Center
Jacksonville, Florida, 32207
Status
Not yet recruiting
Address
AdventHealth Orlando-AdventHealth Medical Group Hematology & Oncology at Orlando
Orlando, Florida, 32804
Status
Not yet recruiting
Address
BRCR Medical Center Inc.
Plantation, Florida, 33322
Status
Withdrawn
Address
Northwestern University
Chicago, Illinois, 60611
Status
Completed
Address
Local Institution - 112
Chicago, Illinois, 60612
Status
Not yet recruiting
Address
University Of Kentucky Markey Cancer Center
Lexington, Kentucky, 40536-0293
Status
Not yet recruiting
Address
Tulane University School Of Medicine
New Orleans, Louisiana, 70112
Status
Not yet recruiting
Address
Tufts Medical Center - PPDS
Boston, Massachusetts, 02111
Status
Withdrawn
Address
University of Massachusetts
Worcester, Massachusetts, 01655
Status
Recruiting
Address
University Of Michigan Comprehensive Cancer Center
Ann Arbor, Michigan, 48109
Status
Not yet recruiting
Address
Spectrum Health Medical Group
Grand Rapids, Michigan, 49503
Status
Completed
Address
Local Institution - 108
Saint Louis, Missouri, 63110
Status
Recruiting
Address
John Theurer Cancer Center
Hackensack, New Jersey, 07601-2191
Status
Withdrawn
Address
Memorial Sloan Kettering Cancer Center
New York, New York, 10021-6094
Status
Recruiting
Address
Mount Sinai Medical Center
New York, New York, 10029
Status
Withdrawn
Address
Cleveland Clinic Foundation
Cleveland, Ohio, 44195
Status
Not yet recruiting
Address
University of Pittsburg Medical Center
Pittsburgh, Pennsylvania, 15213
Status
Recruiting
Address
West Penn Allegheny Lupus Center of Excellence
Pittsburgh, Pennsylvania, 15224
Status
Not yet recruiting
Address
University of Tennessee Medical Center
Knoxville, Tennessee, 37920
Status
Recruiting
Address
The University of Texas - MD Anderson Cancer Center
Houston, Texas, 77030
Status
Withdrawn
Address
CTRC at The UT Health Science Center at San Antonio
San Antonio, Texas, 78229
Status
Recruiting
Address
University of Utah - Huntsman Cancer Institute
Salt Lake City, Utah, 84112
International Sites
Status
Not yet recruiting
Address
Local Institution - 173
La Plata, Buenos Aires, B1900AX
Status
Recruiting
Address
Monash Medical Centre
Clayton, Victoria, 3168
Status
Recruiting
Address
The Alfred Hospital
Melbourne, Victoria, 3004
Status
Recruiting
Address
Gosford Hospital
Gosford, , 2250
Status
Recruiting
Address
Royal Hobart Hospital
Hobart, , 7000
Status
Recruiting
Address
Medizinische Universitat Graz
Graz, , 8036
Status
Recruiting
Address
Krankenhaus der Elisabethinen Linz, I Interne Abteilung
Linz, , 4020
Status
Recruiting
Address
Medizinische Universitat Wien, Universitatsklinik fur Dermatologie. Abteilung fur Immundermatologie
Vienna, , 1090
Status
Completed
Address
Hanusch Krankenhaus
Wien, , 1140
Status
Recruiting
Address
AZ Sint-Jan AV Brugge
Brugge, , 8000
Status
Recruiting
Address
Cliniques Universitaires Saint-Luc
Brussels, , 1200
Status
Recruiting
Address
Virga Jessa Ziekenhuis
Hasselt, , 3500
Status
Recruiting
Address
Uz Leuven
Leuven, , 3000
Status
Not yet recruiting
Address
Local Institution - 319
Liège, , 4000
Status
Recruiting
Address
AZ Delta
Roeselare, , 8800
Status
Recruiting
Address
Centre Hospitalier Peltzer - La Tourelle
Verviers, , 4800
Status
Recruiting
Address
Cliniques Universitaires UCL de Mont-Godine
Yvoir, , 5530
Status
Recruiting
Address
Tom Baker Cancer Centre
Calgary, Alberta, T2N 4N2
Status
Recruiting
Address
University Of Alberta Hospital
Edmonton, Alberta, T6G 2S2
Status
Recruiting
Address
St. Paul'S Hospital
Vancouver, British Columbia, V6Z 2A5
Status
Withdrawn
Address
Local Institution - 184
Saint John, New Brunswick, E2L 4L2
Status
Recruiting
Address
University Hospital - London Health Sciences Centre
London, Ontario, N6C 6B5
Status
Recruiting
Address
Princess Margaret Cancer Centre
Toronto, Ontario, M5G 2M9
Status
Recruiting
Address
Hopital Maisonneuve-Rosemont
Montreal, Quebec, H1T 2M4
Status
Recruiting
Address
Sir Mortimer B. Davis - Jewish Genl
Montreal, Quebec, H3T 1E2
Status
Completed
Address
Centre Hospitalier Universitaire de Sherbrooke-Hospital Fleurimont
Sherbrooke, Quebec, J1H5N4
Status
Not yet recruiting
Address
Local Institution - 191
La Serena, Coquimbo, 1720430
Status
Recruiting
Address
Nanfang Hospital of Southern Medical University
Guangzhou, Guangdong, 510515
Status
Recruiting
Address
The First Affiliated Hospital of Nanyang Medical College
Nanyang, Henan,
Status
Recruiting
Address
Local Institution - 812
Changsha, Hunan, 410008
Status
Recruiting
Address
Local Institution - 804
Nanjing, Jiangsu, 210029
Status
Recruiting
Address
Local Institution - 820
Nanchang, Jiangxi, 330006
Status
Recruiting
Address
Nanchang University - The Second Affiliated Hospital
Nanchang, Jiangxi, 330008
Status
Recruiting
Address
Local Institution - 821
Qingdao, Shandong, 0
Status
Recruiting
Address
Local Institution - 816
Taiyuan, Shanxi, 030001
Status
Recruiting
Address
Local Institution - 819
Kunming, Yunnan, 650101
Status
Recruiting
Address
Local Institution - 806
Beijing, , 100730
Status
Recruiting
Address
First Hospital of Jilin University
Changchun, , 130021
Status
Recruiting
Address
Local Institution - 805
Guangzhou, , 510030
Status
Recruiting
Address
The First Affiliated Hospital Of Harbin Medical University
Harbin, , 150081
Status
Recruiting
Address
Ruijin Hospital Shanghai Jiaotong University
Shanghai, , 200025
Status
Recruiting
Address
Local Institution - 801
Shanghai, , 200233
Status
Recruiting
Address
Local Institution - 811
Suzhou, , 215006
Status
Recruiting
Address
Chinese Academy of Medical Sciences & Peking Union Medical College
Tianjin, , 300041
Status
Recruiting
Address
Tianjin Medical University General Hospital
Tianjin, , 300052
Status
Recruiting
Address
Local Institution - 810
Zhengzhou, , 0
Status
Not yet recruiting
Address
Local Institution - 161
Medellin, Antioquia, 50034
Status
Not yet recruiting
Address
Local Institution - 162
Floridablanca, Soto, 681002
Status
Recruiting
Address
Vseobecna Fakultni Nemocnice V Praze
Prague 2, , 128 08
Status
Recruiting
Address
CHRU Hopital du bocage
Angers, , 49033
Status
Recruiting
Address
Hopital Henri Mondor
Creteil, , 94010
Status
Recruiting
Address
Chu De Grenoble
Grenoble, , 38043
Status
Recruiting
Address
CHRU de Lille-Hopital Claude Huriez
Lille, , 59037
Status
Recruiting
Address
Centre Leon Berard
Lyon, , 69008
Status
Recruiting
Address
CHU de Nice Archet I
Nice, , 06202
Status
Recruiting
Address
Centre Hospitalier Universitaire de Nimes (CHU) - Hopital Universitaire Caremeau
Nimes Cedex 9, , 30029
Status
Recruiting
Address
Hopital Saint Louis
Paris Cedex 10, , 75475
Status
Recruiting
Address
Groupe Hospitalier Sud Hopital Haut Leveque USN
Pessac, , 33604
Status
Recruiting
Address
CHU La Miletrie
Poitiers Cedex, , 86021
Status
Recruiting
Address
ICANS Institut de cancerologie Strasbourg Europe
Strasbourg, , 67200
Status
Recruiting
Address
Institut Universitaire du Cancer de Toulouse - Oncopole
Toulouse Cedex 9, , 31059
Status
Recruiting
Address
Unviversitatsklinikum Aachen
Aachen, , 52074
Status
Recruiting
Address
Stauferklinikum Schwab. Gmund
Baden-Warttemberg, , 73557
Status
Recruiting
Address
Universitaetsklinikum Duesseldorf
Dusseldorf, , 40225
Status
Recruiting
Address
Universitatsklinikum Halle Saale
Halle, , 06120
Status
Recruiting
Address
OncoResearch Lerchenfeld GmbH
Hamburg, , 22081
Status
Recruiting
Address
Universitaetsklinikum Jena
Jena, , 07740
Status
Recruiting
Address
Universitatsklinikum Leipzig
Leipzig, , 04103
Status
Recruiting
Address
Universitaetsklinikum Mannheim
Mannheim, , 68167
Status
Recruiting
Address
Johannes Wiesling Klinikum Minden
Minden, , 32429
Status
Recruiting
Address
University Hospital of Alexandroupolis
Alexandroupolis, , 08100
Status
Recruiting
Address
Evangelismos General Hospital of Athens
Athens, , 10676
Status
Completed
Address
General Hospital of Athens "Laiko"
Athens, , 11 527
Status
Recruiting
Address
Attikon University General Hospital
Athens, , 12464
Status
Recruiting
Address
University General Hospital of Patras
Rio Patras, , 26500
Status
Recruiting
Address
Georgios Papanikolaou General Hospital of Thessaloniki
Thessaloniki, , 57010
Status
Recruiting
Address
Queen Mary Hospital
Hong Kong, , 0
Status
Recruiting
Address
Prince of Wales Hospital the Chinese University of Hong Kong
Sha Tin, , 0
Status
Recruiting
Address
Local Institution - 462
Budapest, , 1096
Status
Recruiting
Address
Petz Aladár Egyetemi Oktató Kórház
Gyor, , 9023
Status
Withdrawn
Address
Local Institution - 461
Kaposvar, , 7400
Status
Recruiting
Address
Local Institution - 423
Cork, , T12 DFK4
Status
Recruiting
Address
Mater Misercordiae Hospital
Dublin 7, , 7
Status
Recruiting
Address
St James Hospital
Dublin, , Dublin 8
Status
Recruiting
Address
Rambam Medical Center
Haifa, , 31096
Status
Recruiting
Address
Hadassah Medical Organization
Jerusalem, , 91120
Status
Recruiting
Address
Meir Medical Center
Kfar-Saba, , 44281
Status
Recruiting
Address
Tel-Aviv Sourasky Medical Center
Tel-Aviv, , 64239
Status
Recruiting
Address
Shamir Medical Center - Assaf Harofeh
Zerifin, , 70300
Status
Not yet recruiting
Address
Local Institution - 258
Meldola (fc), Fc, 47014
Status
Recruiting
Address
Azienda Ospedaliero Universitaria Ospedali Riuniti Umberto I, G.M. Lancisi, G. Salesi
Ancona, , 60126
Status
Recruiting
Address
Azienda Ospedaliero-Universitaria di Bologna - Policlinico S.Orsola-Malpighi
Bologna, , 40138
Status
Not yet recruiting
Address
Local Institution - 256
Brescia, , 25123
Status
Recruiting
Address
Azienda Ospedaliero - Universitaria Policlinico - Vittorio Emanuele - Ospedale Gaspare Rodolico
Catania, , 95123
Status
Recruiting
Address
Azienda Ospedaliera Universitaria Careggi
Firenze, , 50134
Status
Not yet recruiting
Address
Local Institution - 255
Milano, , 20122
Status
Recruiting
Address
Azienda Ospedaliera Universitaria Federico Ii
Napoli Campania, , 80131
Status
Recruiting
Address
A.O.U. Maggiore della Carit
Novara, , 28100
Status
Recruiting
Address
Azienda Ospedaliera Di Padova
Padova, , 35128
Status
Recruiting
Address
Azienda Ospedaliero Universitaria Pisana
Pisa, , 56100
Status
Recruiting
Address
Grande Ospedale Metropolitano Bianchi-Melacrino-Morelli
Reggio Di Calabria, , 89124
Status
Recruiting
Address
Azienda Policlinico Universitario Umberto I
Roma, , 00100
Status
Withdrawn
Address
Local Institution - 0812
Roma, , 00100
Status
Recruiting
Address
Azienda Ospedaliera Sant Andrea
Roma, , 00189
Status
Recruiting
Address
Ospedale S Eugenio
Roma, , 144
Status
Completed
Address
Local Institution - 245
Terni, , 05100
Status
Not yet recruiting
Address
Local Institution - 259
Torino, , 10126
Status
Recruiting
Address
Universita degli Studi dell'Insubria - Ospedale di Circolo e Fondazione Macchi - Varese
Varese, , 21100
Status
Not yet recruiting
Address
Local Institution - 257
Verona, , 37134
Status
Recruiting
Address
The Japanese Red Cross Nagasaki Genbaku Hospital
Nagasaki-shi, Nagasaki, 852-8511
Status
Recruiting
Address
Kindai University Hospital- Osakasayama Campus
Osakasayama, Osaka, 5898511
Status
Recruiting
Address
Juntendo University Hospital
Bunkyo-ku, Tokyo, 113-0033
Status
Recruiting
Address
Aomori Prefectural Central Hospital
Aomori, , 030-8553
Status
Recruiting
Address
Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital
Bunkyo-ku, , 113-8677
Status
Recruiting
Address
University of Yamanashi Hospital
Chuo, , 409-3898
Status
Recruiting
Address
Tokai University Hospital
Isehara City, Kanagawa, , 259-1193
Status
Recruiting
Address
Local Institution - 717
Kamakura, , 247-8533
Status
Recruiting
Address
Kameda General Hospital
Kamogawa, , 296-8602
Status
Recruiting
Address
Gunma University Hospital
Maebashi, , 371-8511
Status
Recruiting
Address
University of Miyazaki Hospital
Miyazaki, , 889-1692
Status
Recruiting
Address
Local Institution - 716
Ogaki, , 503-8502
Status
Recruiting
Address
Osaka Metropolitan university Hospital
Osaka, , 545-8586
Status
Completed
Address
Sapporo Hokuyu Hospital
Sapporo, , 003-0006
Status
Recruiting
Address
NTT Medical Center Tokyo
Shinagawa-ku, Tokyo, , 141-8625
Status
Recruiting
Address
Tokyo Women's Medical University Hospital
Shinjuku City, , 162-8666
Status
Completed
Address
Tokyo Medical University Hospital
Shinjyuku-ku, , 160-0023
Status
Not yet recruiting
Address
Toyohashi Municipal Hospital
Toyohashi, , 441-8570
Status
Recruiting
Address
Kyungpook National University Hospital
Daegu, , 700-721
Status
Recruiting
Address
Chonnam National University Hwasun Hospital
Hwasun-Gun, , 58128
Status
Recruiting
Address
Seoul National University Bundang Hospital
Seongnam-si, , 13620
Status
Recruiting
Address
Samsung Medical Center
Seoul, , 06351
Status
Recruiting
Address
The Catholic University of Korea Seoul - Saint Mary's Hospital
Seoul, , 06591
Status
Recruiting
Address
Seoul National University Hospital
Seoul, , 3080
Status
Recruiting
Address
Asan Medical Center
Seoul, , 5505
Status
Not yet recruiting
Address
Local Institution - 551
Saida, South, 652
Status
Not yet recruiting
Address
American Univ of Beirut Med Center
Badaro Beirut, , 11072280
Status
Not yet recruiting
Address
Local Institution - 552
Beirut, , 11-3288
Status
Recruiting
Address
Uniwersyteckie Centrum Kliniczne
Gdansk, , 80-952
Status
Recruiting
Address
Samodzielny Publiczny Zaklad Opieki Zdrowotnej Szpital Uniwersytecki w Krakowie
Krakow, , 31-501
Status
Recruiting
Address
Wojewódzki Szpital Specjalistyczny im. M. Kopernika w Lodzi
Lodz, , 93-510
Status
Recruiting
Address
ALVAMED
Poznan, , 61-696
Status
Recruiting
Address
Specjalistyczny Szpital im. dra Alfreda Sokolowskiego
Walbrzych, , 58-309
Status
Recruiting
Address
Samodzielny Publiczny Szpital Kliniczny Nr 1 we Wroclawiu
Wroclaw, , 50367
Status
Not yet recruiting
Address
Hospital Auxilio Mutuo, Cancer Center
San Juan, , 00919
Status
Recruiting
Address
Local Institution - 395
Craiova, Dolj, 200143
Status
Withdrawn
Address
Local Institution - 392
Timisoara, Timis, 300041
Status
Recruiting
Address
Local Institution - 393
Brasov, , 500052
Status
Recruiting
Address
Local Institution - 391
Bucharest, , 022328
Status
Recruiting
Address
Local Institution - 394
Cluj-Napoca, , 400015
Status
Completed
Address
Moscow State Healthcare Institution City clinical hospital n.a. S.P.Botkin
Moscow, , 125284
Status
Completed
Address
Federal Centre of Heart, Blood and Endocrinology of Rosmed technlologies V.A. Almazov
St Petersburg, , 197341
Status
Completed
Address
First St Petersburg State Medical University na IP Pavlov
St. Petersburg, , 197022
Status
Recruiting
Address
Hospital Clinic de Barcelona
Barcelona, , 08036
Status
Recruiting
Address
Hospital Universitari Germans Trias i Pujol ICO Badalona
Barcelona, , 08916
Status
Recruiting
Address
Hospital Virgenes de las Nieves
Granada, , 18014
Status
Recruiting
Address
Hospital Universitario De Gran Canaria Dr. Negrin
Las Palmas de Gran Canaria, , 35012
Status
Recruiting
Address
Hospital Universitario Ramón y Cajal
Madrid, , 28034
Status
Recruiting
Address
Hospital Universitario 12 De Octubre
Madrid, , 28041
Status
Recruiting
Address
Hospital son Espases
Palma de Mallorca, , 7120
Status
Recruiting
Address
Universitario de Salamanca - Hospital Clinico
Salamanca, , 37007
Status
Recruiting
Address
Complejo Hospitalario Universitario De Santiago
Santiago de Compostela, , 15706
Status
Recruiting
Address
Hospital Universitario Virgen del Rocio
Seville, , 41013
Status
Recruiting
Address
Hospital Clinico Universitario De Valencia
Valencia, , 46010
Status
Recruiting
Address
Nottingham City Hospital
Nottingham, Nottinghamshire, NG5 1PB
Status
Recruiting
Address
Heart of England NHS Foundation Trust
Birmingham, , B9 5SS
Status
Recruiting
Address
United Lincolnshire Hospitals NHS Trust
Boston, , PE21 9QS
Status
Withdrawn
Address
Local Institution - 361
London, , SE1 9RT
Status
Recruiting
Address
Churchhill Hospital
Oxford, , OX3 7LI